We use cognitive network modelling to understand the function of the brain.

What is cognitive network modelling? We use mathematical models to analyze data (participants’ behaviour and brain activity) recorded during cognitive tasks. Through the use of these models, it is possible to infer underlying neural mechanisms that help us understand the participants’ mental health.

Our long-term vision is to leverage cognitive network modelling to help patients in the clinic. The insights we gain from modelling bear clinical utility, translating into diagnostic markers, improving treatment response prediction and aiding in averting severe consequences of mental illness.

Cognitive Network Modelling

Cognitive network modelling employs mathematical models to infer hidden neural mechanisms from recordings of behaviour and brain activity–functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) data–acquired during cognitive tasks. We utilize a suite of mathematical models, including hierarchical Bayesian, reinforcement learning, and machine learning algorithms, to infer underlying cognitive and neuronal mechanisms.

On one axis, our research examines how basic learning signals, such as predictions and “correction” signals or prediction errors, are represented in the brain using probabilistic learning tasks and multimodal imaging (EEG and fMRI). This foundational knowledge serves as a substrate for our parallel line of inquiry that investigates how distortions in the representation of these learning signals contribute to maladaptive behaviours and pathological states. Specifically, we are interested in how these mechanisms could underpin the neurobiology of severe mental disorders, including schizophrenia and major depression.

Clinical Utility

On the second axis, our goal is to translate these neurobiological insights into early diagnostic markers and therapeutic interventions. There are three main research pillars that my team is currently pursuing: psychosis, treatment response prediction, and suicidality:

Psychosis

First, we examine the role of neuromodulation in supporting learning and decision-making under uncertainty using advanced fMRI, to better understand how disruptions in neuromodulation across dopaminergic, cholinergic, serotonergic, and noradrenergic systems can lead to the emergence of core symptoms, such as paranoia in psychosis.

Relevant Publications

Publication

August 1, 2023

Hauke, D.J. and Charlton, C.E. and Schmit, A. and Griffiths, J. and Woods, S.W. and Ford, J.M. and Srihari, V.H. and Roth, V. and Diaconescu, A.O. and Mathalon, D.H.

Publication

July 1, 2022

Hauke, D.J. and Roth, V. and Karvelis, P. and Adams, R.A. and Moritz, S. and Borgwardt, S. and Diaconescu, A.O. and Andreou, C.

Publication

September 1, 2019

Diaconescu, A.O. and Hauke, D.J. and Borgwardt, S.

Treatment Response Prediction

The second research pillar is focused on evaluating the efficacy of computational modelling when applied to electrophysiological or neuroimaging data to predict treatment response in individuals who have been diagnosed with either psychosis or major depressive disorder.

Relevant Publications

Publication

April 25, 2023

Bedford, P. and Hauke, D.J. and Wang, Z. and Roth, V. and Nagy-Huber, M. and Holze, F. and Ley, L. and Vizeli, P. and Liechti, M.E. and Borgwardt, S. and Müller, F. and Diaconescu, A.O.

Publication

October 1, 2022

Karvelis, P. and Charlton, C.E. and Allohverdi, S.G. and Bedford, P. and Hauke, D.J. and Diaconescu, A.O.

Publication

July 1, 2022

Hauke, D.J. and Roth, V. and Karvelis, P. and Adams, R.A. and Moritz, S. and Borgwardt, S. and Diaconescu, A.O. and Andreou, C.

Suicidality

The third pillar focuses on the application of computational modelling for averting severe consequences of mental illness, such as the emergence of suicidal thoughts and behaviours or psychosis spectrum symptoms in help-seeking youth.

Relevant Publications

Publication

May 29, 2024

Diaconescu A.O., Karvelis P., Hauke D.J.

Publication

March 20, 2023

Karvelis, P. and Paulus, M.P. and Diaconescu, A.O.

Publication

March 31, 2022

Karvelis, P. and Diaconescu, A.O.

Contact us!

Email Dr. Diaconescu at andreea.diaconescu@camh.ca

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