We use cognitive network modelling to understand the function of the brain.
Our long-term vision is to leverage cognitive network modelling to help patients in the clinic. The insights we gain from modelling bear clinical utility, translating into diagnostic markers, improving treatment response prediction and aiding in averting severe consequences of mental illness.
Cognitive Network Modelling
Cognitive network modelling employs mathematical models to infer hidden neural mechanisms from recordings of behaviour and brain activity–functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) data–acquired during cognitive tasks. We utilize a suite of mathematical models, including hierarchical Bayesian, reinforcement learning, and machine learning algorithms, to infer underlying cognitive and neuronal mechanisms.
On one axis, our research examines how basic learning signals, such as predictions and “correction” signals or prediction errors, are represented in the brain using probabilistic learning tasks and multimodal imaging (EEG and fMRI). This foundational knowledge serves as a substrate for our parallel line of inquiry that investigates how distortions in the representation of these learning signals contribute to maladaptive behaviours and pathological states. Specifically, we are interested in how these mechanisms could underpin the neurobiology of severe mental disorders, including schizophrenia and major depression.
Clinical Utility
Psychosis
First, we examine the role of neuromodulation in supporting learning and decision-making under uncertainty using advanced fMRI, to better understand how disruptions in neuromodulation across dopaminergic, cholinergic, serotonergic, and noradrenergic systems can lead to the emergence of core symptoms, such as paranoia in psychosis.
Relevant Publications
Publication
August 1, 2023
Hauke, D.J. and Charlton, C.E. and Schmit, A. and Griffiths, J. and Woods, S.W. and Ford, J.M. and Srihari, V.H. and Roth, V. and Diaconescu, A.O. and Mathalon, D.H.
Publication
July 1, 2022
Hauke, D.J. and Roth, V. and Karvelis, P. and Adams, R.A. and Moritz, S. and Borgwardt, S. and Diaconescu, A.O. and Andreou, C.
Publication
September 1, 2019
Diaconescu, A.O. and Hauke, D.J. and Borgwardt, S.
Treatment Response Prediction
The second research pillar is focused on evaluating the efficacy of computational modelling when applied to electrophysiological or neuroimaging data to predict treatment response in individuals who have been diagnosed with either psychosis or major depressive disorder.
Relevant Publications
Publication
April 25, 2023
Bedford, P. and Hauke, D.J. and Wang, Z. and Roth, V. and Nagy-Huber, M. and Holze, F. and Ley, L. and Vizeli, P. and Liechti, M.E. and Borgwardt, S. and Müller, F. and Diaconescu, A.O.
Publication
October 1, 2022
Karvelis, P. and Charlton, C.E. and Allohverdi, S.G. and Bedford, P. and Hauke, D.J. and Diaconescu, A.O.
Publication
July 1, 2022
Hauke, D.J. and Roth, V. and Karvelis, P. and Adams, R.A. and Moritz, S. and Borgwardt, S. and Diaconescu, A.O. and Andreou, C.
Suicidality
The third pillar focuses on the application of computational modelling for averting severe consequences of mental illness, such as the emergence of suicidal thoughts and behaviours or psychosis spectrum symptoms in help-seeking youth.
Relevant Publications
Publication
May 29, 2024
Diaconescu A.O., Karvelis P., Hauke D.J.
Publication
March 20, 2023
Karvelis, P. and Paulus, M.P. and Diaconescu, A.O.
Publication
March 31, 2022
Karvelis, P. and Diaconescu, A.O.
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